Ozone & Prolozone Therapy

What Is Ozone & Prolozone Therapy?


Ozone and Prolozone Therapy are innovative regenerative treatments designed to support healing at the cellular level. Both involve the use of medical-grade ozone gas (O3), which delivers a powerful oxygen boost to tissues and stimulates the body’s natural repair processes.


Ozone Therapy delivers oxygen directly into tissues to increase cellular energy (ATP), reduce inflammation, and promote regeneration. Prolozone Therapy combines ozone with homeopathic injections, enhancing healing and providing faster pain relief for chronic joint and tissue conditions.


How It Works



Ozone Therapy: When ozone gas is injected into tissue, it quickly breaks apart and floods the surrounding area with oxygen. This boosts mitochondria function, increases oxygen absorption by up to 1,000%, and stimulates the release of natural healing compounds such as stem cells, cytokines, growth factors, and collagen.


After its first appearance in the 1980s, herniated disc oxygen therapy has gained popularity in Asia and Europe. Existing work on oxygen-ozone therapy has shown a reduction in the herniated disk effects of 70-80% of patients following diagnosis. Patients often encounter few problems with oxygen ozone therapy, which is potentially as significant as the success rate.


Spine researchers are researching oxygen-ozone therapy in more depth, and many have discovered that it has the same effects than existing therapies such as surgical discectomy or epidural steroid injections. 


Dr. Kieran Murphy published his team's research and results on oxygen-ozone therapy, noting that the effects of pain and purpose of patients who received oxygen-ozone therapy are close to discectomy of patients. Studies have also shown that in contrast to conventional surgical procedures, the risk and recovery time are lesser with oxygen-ozone injections.


A 2014 research explored the long-term efficacy of oxygen-ozone therapy by targeting patients ten years after initial diagnosis. For nearly 75% of patients with herniated discs, oxygen-ozone injections are assumed by the authors — the gain lasts for ten years. The writers added that before contemplating surgery the therapy is worthwhile.


Ozone (O₃) is a highly reactive molecule made up of three oxygen atoms in a dynamically unstable structure. Discovered in the 1840s and used medically for over a century, ozone has transformed from a misunderstood molecule to a cutting-edge therapy that works at the cellular level to restore balance and stimulate your body’s natural healing mechanisms.


As far back as 1896, Nikola Tesla patented the first O₃ generator in the US, later forming the “Tesla Ozone Company” specifically for medical applications. Today, medical ozone therapy is a safe, science-backed tool with over a century of clinical research behind it.


In medical settings, ozone is used in precise, controlled doses to create a mild oxidative “spark” that encourages the body to rebalance, repair, and regenerate. Unlike many conventional treatments that simply mask symptoms, ozone therapy addresses the root causes of fatigue, inflammation, poor circulation, and immune dysfunction.



Transformative Benefits of Ozone Therapy


Medical ozone delivers comprehensive health benefits through multiple pathways, working at the cellular level to restore and optimize your body’s natural functions.


  • Powerful Anti-Infective Action
  • Destroys harmful bacteria, viruses, fungi, and pathogens by oxidizing their protective membranes and DNA.
  • Strengthens your body's natural defenses against infections.
  • Provides targeted support for viral infections and chronic microbial challenges.
  • Enhanced Oxygen Delivery and Energy Production
  • Reduced Fatigue and Inflammation
  • Improved Daily Performance
  • Immune System Balance
  • Protection Against Oxidative Stress
  • Support for Essential Body Functions


Conditions Ozone Therapy May Support


  • Chronic fatigue.
  • Autoimmune disorders.
  • Fibromyalgia.
  • Lyme disease.
  • Long COVID symptoms.
  • Circulatory issues.
  • Inflammatory conditions.
  • Difficult-to-resolve medical conditions.


How Does Ozone Therapy Work?


  • Cellular Activation: This treatment triggers your cells to repair themselves and produce more natural antioxidants. The process reduces inflammation and helps your cells work the way they should.


  • Better Oxygen Use: Your body learns to use oxygen more efficiently, which means more energy, better endurance, and improved performance throughout the day.


  • Enhanced Circulation: Red blood cells become more flexible, allowing them to travel through even the smallest blood vessels. This delivers more oxygen to every part of your body where it's needed.


  • Increased Energy Production: By boosting ATP production (the fuel your body runs on), this therapy provides sustained energy that lasts all day long.


Why Choose New Leaf Health


Expert Providers Trained in Medical Ozone Therapy


Our team has specialized training in medical ozone therapy protocols, ensuring you receive care from knowledgeable professionals who understand the science and application of this advanced treatment.


  • Evidence-Based Protocols
  • Professional Equipment and Clinical Safety Protocols
  • Whole-Body, Functional Approach to Healing
  • Personalized Care and Clear Communication



Frequently Asked Questions


Is ozone therapy safe?


Yes, when administered by trained professionals using proper protocols, ozone therapy has an excellent safety profile. Medical ozone differs significantly from environmental ozone and has been used therapeutically for over a century. At New Leaf Health we use state-of-the-art equipment and strict clinical protocols to ensure your treatment is both safe and effective.


How many treatments will I need?


What conditions respond well to ozone therapy?


Will ozone therapy interfere with my current treatments?


Can ozone therapy help with both weakened immunity and autoimmune conditions?


Prolozone Therapy


This two-step treatment begins with a homeopathic injection followed immediately by ozone. The synergy between the two reduces inflammation, triggers pain relief, and accelerates repair of joints, discs, and soft tissue.


What to Expect During Treatment



  • Mild burning sensation at the injection site for 1–2 minutes
  • Soreness lasting a few minutes to 48 hours in rare cases
  • Heightened healing response for 7–10 days post-treatment
  • Avoid NSAIDs for 24 hours (Omega-3 supplements are allowed)


Patients often report 50–80% reduction in joint pain, improved mobility, and stronger collagen tissue after a series of sessions. Most people experience minimal to no side effects.


Conditions That Respond Well to These Therapies


  • Chronic joint pain
  • Back pain and sciatica
  • Neck pain and disc degeneration
  • Arthritis in knees, hips, shoulders, or hands
  • Rotator cuff injuries
  • Carpal tunnel syndrome
  • Skin conditions like acne, eczema, and herpes simplex
  • Respiratory issues (asthma, bronchitis, COPD)
  • Digestive issues (IBS, colitis)
  • Fatigue, low energy, and slow post-surgical recovery


Safe, Natural, and Non-Surgical


Both Ozone and Prolozone therapies are considered safe and non-invasive. The treatments work with your body—not against it—to restore proper function, reduce inflammation, and eliminate pain at its source.


Prolotherapy, or proliferative therapy, is a regenerative treatment that stimulates the body’s natural healing processes to alleviate pain and improve function. It involves injecting a fluid, typically dextrose or saline, into injured ligaments, tendons, or joints. These injections cause a mild inflammatory response, promoting tissue healing and strengthening the wounded area. Prolotherapy is a less invasive treatment option for chronic musculoskeletal disorders such as arthritis, tendinitis, and back pain, and is a great option for patients seeking complementary or supplemental therapy.


Our team at Venturis Clinic offers prolotherapy, along with many other regenerative medicine options. Some of the many conditions we’ve treated in the past include the following:


  • Lax or Unstable Joints
  • Whiplash
  • Fibromyalgia
  • Joint Sprains
  • Certain Types of Headaches
  • Tennis Elbow
  • Finger, Knee, and Hip Arthritis
  • Chronic Tendonitis
  • Back Pain
  • Plantar Fasciitis
  • Tendon, Muscle, and Ligament Problems
  • Bulging Disc
  • Sciatica


Prolotherapy is a procedure that does not use steroids to provide pain relief. This means it can be used to provide long-term pain relief and, for some, permanent pain relief. When you talk with our team about prolotherapy, we will answer any questions you might have as well as address any concerns. From there, we will assess your needs and create a tailored plan that will help you reach your goals. We are led by Dr. Trites DC, who has more than 25 years of experience in the field, giving you peace of mind that your health is in the best hands.


DUNCAN - Phone: 580.686.0951

1208 N. 10th St Duncan, OK, 73533

DALLAS - Phone: 469.491.7535

17000 Dallas Pkwy, Ste. 215,

Dallas, TX 75248

FAX (both locations): 972.829.8638

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The information provided on this website is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis or treatment. Please set up an appointment with Dr. Tries for questions concerning any medical condition. While we try to update our content often, medical information changes rapidly. Therefore, some information may be out of date.